| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
KDM5A-IN-1 manufacturers
- KDM5A-IN-1
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- $149.00
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2026-07-14
- CAS:1905481-36-8
- Purity: 100.00%
- Supply Ability: 10g
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| | KDM5A-IN-1 Basic information |
| Product Name: | KDM5A-IN-1 | | Synonyms: | KDM5A-IN-1;KDM5A inhibitor 1;Cyclopropanecarboxamide, N-[(3R)-1-[[5-(1-methylethyl)-1H-pyrazol-3-yl]carbonyl]-3-pyrrolidinyl]-;KDM5A IN 1,KDM5AIN1,KDM-5A-IN-1;KDM5A-IN-1, 10 mM in DMSO | | CAS: | 1905481-36-8 | | MF: | C15H22N4O2 | | MW: | 290.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1905481-36-8.mol |  |
| | KDM5A-IN-1 Chemical Properties |
| Boiling point | 592.6±50.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 50 mg/mL (172.20 mM) | | form | Solid | | pka | 12.68±0.10(Predicted) | | color | White to off-white |
| | KDM5A-IN-1 Usage And Synthesis |
| Uses | KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B)[1]. | | in vivo | KDM5A-IN-1 (Compound 50, 5 mg/kg; oral administration; female CD-1 mice) treatment shows moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34) and remarkably low plasma protein binding in mice (40%), with t1/2 of 0.4 hours[1]. | Animal Model: | Female CD-1 mice[1] | | Dosage: | 5 mg/kg | | Administration: | Oral administration (Pharmacokinetic study) | | Result: | Moderate clearance (28 mL/min/kg) in mice with good oral bioavailability (F% 34), and showed remarkably low plasma protein binding in mice (40%).
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| | IC 50 | KDM5 | | References | [1] Liang J, et al. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2974-2981. DOI:10.1016/j.bmcl.2017.05.016 |
| | KDM5A-IN-1 Preparation Products And Raw materials |
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