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| | FSL-1 lipoprotein, synthetic Basic information |
| Product Name: | FSL-1 lipoprotein, synthetic | | Synonyms: | FSL-1 lipoprotein, synthetic;(R)-FSL-1;FSL-1 >=80% (HPLC);L-Phenylalanine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-;FSL-1, TLR2/6 agonist;FSL-1 ，S8428 | | CAS: | 322455-70-9 | | MF: | C84H140N14O18S | | MW: | 1666.1584 | | EINECS: | | | Product Categories: | | | Mol File: | 322455-70-9.mol |  |
| | FSL-1 lipoprotein, synthetic Chemical Properties |
| Boiling point | 1659.8±65.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | powder | | pka | 3.46±0.10(Predicted) | | color | Colorless | | Water Solubility | H2O: soluble | | Sequence | Ser-(2,3-Bispalmitoyloxypropyl)-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | FSL-1 lipoprotein, synthetic Usage And Synthesis |
| Uses | FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1][2]. | | Biological Activity | FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein th at acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-KB. FSL-1 is based on the N-terminal part of the 44-kDa lipoprotein LP44 of Mycoplasma salivarium. FSL-1 showed higher stimulatory activity than MALP-2 in its ability to induce TNF-α production in macrophages and NF-KB in TLR2/TLR6 transfected HEK293 cells.', 'FSL-1 is a bacterial-derived toll-like receptor 2/6 agonist. It is capable of increasing resistance to herpes simplex virus type 2 (HSV-2) infection. | | IC 50 | TLR2; TLR6 | | storage | +4°C | | References | [1] William A Rose 2nd, et al. FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. Virol J. 2009 Nov 10;6:195. DOI:10.1186/1743-422X-6-195
[2] Rasheed Ahmad, et al. FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells. Cell Physiol Biochem. 2014;34(3):929-42. DOI:10.1159/000366310 |
| | FSL-1 lipoprotein, synthetic Preparation Products And Raw materials |
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