- 4-Hydroxythiobenzamide
-
- $16.00 / 25ASSAYS
-
2025-12-26
- CAS:25984-63-8
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 100mt
- 4-Hydroxythiobenzamide
-
- $0.00 / 1G/KG
-
2025-12-26
- CAS:25984-63-8
- Min. Order: 1G/KG
- Purity: 99%
- Supply Ability: 100MT
- 4-Hydroxythiobenzamide
-
- $0.00 / 1kg
-
2025-12-26
- CAS:25984-63-8
- Min. Order: 0.001kg
- Purity: 99%
- Supply Ability: 2000000kg
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| | 4-Hydroxythiobenzamide Basic information | | Uses |
| | 4-Hydroxythiobenzamide Chemical Properties |
| Melting point | 181-185℃ | | Boiling point | 320.4±44.0 °C(Predicted) | | density | 1.338±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 9.24±0.26(Predicted) | | color | Light Yellow | | InChI | InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10) | | InChIKey | VDTNKXSVUGXUOJ-UHFFFAOYSA-N | | SMILES | C1(C(N)=S)=CC=C(O)C=C1 | | CAS DataBase Reference | 25984-63-8(CAS DataBase Reference) |
| | 4-Hydroxythiobenzamide Usage And Synthesis |
| Uses |
4-Hydroxythiobenzamide(25984-63-8) is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
| | Description | 4-Hydroxythiobenzamide is a key intermediate in febuxostat, a highly effective drug for treating gout. In addition, 4-hydroxythiobenzamide has been used to synthesize a variety of bioactive compounds, such as PPARγ agonists (used to increase high-density lipoprotein cholesterol levels) and potent CDK5 inhibitors (used in neurological disorders and cancer research). | | Chemical Properties | 4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol. | | Uses | febuxostat intermediate | | Uses | 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease. | | Synthesis |
4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.
| | References | [1] Patent: US2005/75503, 2005, A1. Location in patent: Page/Page column 3
[2] Patent: US2012/78013, 2012, A1. Location in patent: Page/Page column 4
[3] Patent: CN106928108, 2017, A. Location in patent: Paragraph 0043; 0044; 0046; 0048; 0063; 0065; 0067; 0071
[4] Patent: WO2016/46836, 2016, A2. Location in patent: Page/Page column 3
[5] Synthetic Communications, 2000, vol. 30, # 6, p. 1083 - 1094 |
| | 4-Hydroxythiobenzamide Preparation Products And Raw materials |
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