1384268-04-5
| 中文名称 | 1384268-04-5 |
|---|---|
| 中文同义词 | HIF-1抑制剂(SYP-5);化合物SYP-5;(E)-1-(5-羟基-2,2-二甲基-2H-苯并吡喃-6-基)-3-(噻吩-2-基)丙-2-烯-1-酮;(E)-1-(5-羟基-2,2-二甲基-2H-2H-CHROMEN-6-YL)-3-(THIOPHEN-2-YL)PROP-2-EN-1-1-ONE;化合物SYP-5,10 MM DMSO 溶液 |
| 英文名称 | SYP-5 |
| 英文同义词 | SYP-5;SYP5; SYP 5;2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-;SYP-5 >=98% (HPLC);SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase;(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one;SYP-5, 10 mM in DMSO |
| CAS号 | 1384268-04-5 |
| 分子式 | C18H16O3S |
| 分子量 | 312.38 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1384268-04-5.mol |
| 结构式 |  |
1384268-04-5 性质
| 沸点 | 502.0±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.263±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF:30.0(最大浓度 mg/mL);96.04(最大浓度 mM) DMF:PBS (pH 7.2) (1:2):0.3(最大浓度 mg/mL);0.96(最大浓度. mM) DMSO:25.0(最大浓度 mg/mL);80.03(最大浓度 mM) 乙醇:1.0(最大浓度 mg/mL);3.2(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.12±0.40(Predicted) |
| 颜色 | 黄至橙色 |
| Target | Value |
|
HIF-1
() |
SYP-5 inhibits hypoxia-induced upregulation of HIF-1. SYP-5 inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down-regulated by SYP-5. SYP-5 displays significant inhibition on hypoxia-induced overexpression of VEGF and MMP2 in both cell lines. In the tube formation assay, SYP-5 suppresses angiogenesis induced by hypoxia and VEGF in vitro. SYP-5 also retards the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. SYP-5 specifically inhibits hypoxic induction of luciferase expression in U251-HRE but not in U251-pGL3.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S2937 | 1384268-04-5 SYP-5 | 1384268-04-5 | 5mg | 1286.75元 |
| 2026/06/05 | HY-100693 | 1384268-04-5 SYP-5 | 1384268-04-5 | 5mg | 910元 |