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BOC Sciences |
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16314854226; +8616314854226 |
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inquiry@bocsci.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
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| | Motolimod Basic information |
| Product Name: | Motolimod | | Synonyms: | Estradiol 3-sulfamate;BLE 00084;E2MATE;ES-J 995;Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate;E2MATE|||BLE 00084|||ES-J 995;ZK-190628;J-995 | | CAS: | 172377-52-5 | | MF: | C18H25NO4S | | MW: | 351.46 | | EINECS: | | | Product Categories: | | | Mol File: | 172377-52-5.mol |  |
| | Motolimod Chemical Properties |
| Melting point | 202-204 °C(Solv: methanol (67-56-1)) | | Boiling point | 531.1±60.0 °C(Predicted) | | density | 1.319±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 62.5 mg/mL (177.83 mM) | | pka | 8.88±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | Motolimod Usage And Synthesis |
| Uses | Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. | | in vivo | Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors[2]. | | References | [1] Numazawa M, et al. Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates. Steroids. 2006 May;71(5):371-9. DOI:10.1016/j.steroids.2005.12.004
[2] Pohl O, et al. Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65. DOI:10.1177/1933719114522526 |
| | Motolimod Preparation Products And Raw materials |
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