N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester)

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N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester) Basic information
Product Name:N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester)
Synonyms:N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester);N-(Azido-PEG3)-N-bis(PEG3-Boc);(N3-PEG3)-N-(PEG3-COOtBu)2
CAS:2055042-56-1
MF:C34H66N4O13
MW:738.92
EINECS:
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Mol File:2055042-56-1.mol
N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester) Structure
N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester) Chemical Properties
solubility Soluble in Water, DMSO, DCM, DMF
Safety Information
MSDS Information
N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester) Usage And Synthesis
DescriptionN-(Azido-PEG3)-N-bis(PEG3-t-butyl ester) is a branched reagent. The azide group enables PEGylation via Click Chemistry. The t-butyl protected carboxyl groups can be deprotected under acidic conditions.
UsesN-(Azido-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-bis(PEG3-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Azido-PEG3)-N-Bis-(PEG3-t-butyl ester) Preparation Products And Raw materials
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