| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
KDM5-IN-1 manufacturers
- KDM5-IN-1
-
- $58.00
-
2026-07-14
- CAS:1628210-26-3
- Purity: 99.50%
- Supply Ability: 10g
|
| | KDM5-IN-1 Basic information |
| Product Name: | KDM5-IN-1 | | Synonyms: | KDM5-IN-1;KDM5 inhibitor compound 48;5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;KDM5-IN-48;KDM5 inhibitor 1;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo-;KDM5 IN 1,inhibit,Histone Demethylase,Inhibitor,KDM-5-IN-1,KDM5IN1;KDM5-IN-1, 10 mM in DMSO | | CAS: | 1628210-26-3 | | MF: | C17H20N6O | | MW: | 324.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1628210-26-3.mol |  |
| | KDM5-IN-1 Chemical Properties |
| Boiling point | 527.0±60.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 30 mg/mL (92.48 mM) | | form | Solid | | pka | 3.10±0.10(Predicted) | | color | White to off-white |
| | KDM5-IN-1 Usage And Synthesis |
| Uses | KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. | | in vivo | When dosed orally in mice at 50 mg/kg twice a day, KDM5-IN-1 shows an unbound maximal plasma concentration Cmax>15-fold over its cell EC50, thereby providing a robust chemical probe for studying KDM5 biological functions in vivo[1]. | | IC 50 | KDM5 | | References | [1] Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41. DOI:10.1016/j.bmcl.2016.06.078 |
| | KDM5-IN-1 Preparation Products And Raw materials |
|