| Company Name: |
MedChemexpress LLC
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021-58955995 |
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sales@medchemexpress.cn |
| Products Intro: |
Product Name:Naveglitazar (racemate)
CAS:916085-47-7
Purity:>98% Package:4000RMB/1mg
|
| Company Name: |
Suzhou Chenrui Biotechnology Co. LTD
|
| Tel: |
17625585511 |
| Email: |
1580084073@qq.com |
| Products Intro: |
Product Name:Naveglitazar racemate
CAS:916085-47-7
Purity:98% Package:1g;5g;10g
|
| Company Name: |
RD International Technology Co., Limited
|
| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:Naveglitazar racemate
CAS:916085-47-7
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
|
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| | Naveglitazar (racemate) Basic information |
| | Naveglitazar (racemate) Chemical Properties |
| Boiling point | 587.3±50.0 °C(Predicted) | | density | 1.198±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.54±0.10(Predicted) |
| | Naveglitazar (racemate) Usage And Synthesis |
| Uses | Naveglitazar racemate (LY519818 racemate) is the racemate of Naveglitazar. Naveglitazar is a nonthiozolidinedione peroxisome proliferator-activated receptor (PPAR) α-γ dual, γ-dominant agonist that has shown glucose-lowering potential in animal models[1]. | | in vivo | [14C]Naveglitazar is quickly absorbed and moderately metabolized before elimination. After oral administration, 47, 31, and 62% of the radioactivity, as assessed by AUC values, are circulating as metabolites in mice, rats, and monkeys, respectively. Half-lives for Naveglitazar and radioactivity are similar within each species; however, monkeys have substantially longer half-lives in comparison to mice and rats. Naveglitazar and radioactivity are slowly cleared from the system circulation in all species evaluated[1]. | | References | [1] Yi P, et al. The disposition and metabolism of naveglitazar, a peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist in mice, rats, and monkeys. Drug Metab Dispos. 2007 Jan;35(1):51-61. DOI:10.1124/dmd.106.012328 |
| | Naveglitazar (racemate) Preparation Products And Raw materials |
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