158089-95-3
| 中文名称 | 158089-95-3 |
|---|---|
| 中文同义词 | 化合物 T16817;化合物 S-2474 |
| 英文名称 | S-2474 |
| 英文同义词 | S-2474;2,6-ditert-butyl-4-[(2-ethyl-1,1-dioxo-1,2-thiazolidin-5-ylidene)methyl]phenol;Phenol, 2,6-bis(1,1-dimethylethyl)-4-[(E)-(2-ethyl-1,1-dioxido-5-isothiazolidinylidene)methyl]-;S 2474,S2474 |
| CAS号 | 158089-95-3 |
| 分子式 | C20H31NO3S |
| 分子量 | 365.53 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 158089-95-3.mol |
| 结构式 |  |
158089-95-3 性质
| 熔点 | 135-137 °C |
|---|---|
| 沸点 | 462.7±55.0 °C(Predicted) |
| 密度 | 1.129±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.28±0.50(Predicted) |
|
COX-2 11 nM (IC 50 ) |
COX-1 27 μM (IC 50 ) |
5-LO
|
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, with IC 50 s of 11 nM and 27 μM for COX-2 and COX-1. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC 50 =26±12 nM). S-2474 (10 μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 inhibits the PGD2 generation in a concentration dependent manner (IC 50 =69.8±21.9 nM). S-2474 (10 μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons. S-2474 significantly prevents neurons from undergoing sPLA 2 -IIA-induced cell death. S-2474 completely ameliorates sPLA 2 -IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. Moreover, S-2474 significantly inhibits the sPLA 2 -IIA-induced generation of PGD2. S-2474 inhibits sPLA 2 -IIA-induced neuronal cell death in a concentration-dependent manner (IC 50 = 94 nM).