2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-

2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- Suppliers list

Company Name:	Career Henan Chemica Co
Tel:	+86-0371-86658258 +8613203830695
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Products Intro:	Product Name:JA2131 CAS:6505-99-3 Purity:98% CRYLIU Package:1g;0.1USD

Company Name:	Aladdin Scientific
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Products Intro:	Product Name:JA2131 CAS:6505-99-3 Purity:>=99.0% Package:$240.9/1mg;$540.9/5mg;Bulk package Remarks:99.0%

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:JA2131 CAS:6505-99-3 Package:100mg;2500USD\|25mg;1330USD\|50mg;1730USD

Company Name:	Shanghai Rechem science Co., Ltd.
Tel:	21-31433387 15618786686
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Products Intro:	CAS:6505-99-3 Purity:98% Package:1g;5g;10g

Company Name:	DC Chemicals
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Products Intro:	Product Name:JA2131 CAS:6505-99-3 Purity:98% HPLC Package:100mg；250mg；1g

2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- manufacturers

2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- Basic information

Product Name:	2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-
Synonyms:	2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-;JA2131;1,3-dimethyl-8-(2-morpholin-4-ylethylsulfanyl)-6-sulfanylidene-7H-purin-2-one;JA2131(NSC98003)
CAS:	6505-99-3
MF:	C13H19N5O2S2
MW:	341.45226
EINECS:
Product Categories:
Mol File:	6505-99-3.mol

2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- Chemical Properties

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MSDS Information

2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- Usage And Synthesis

Uses	JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death[1][2].
Biological Activity	JA2131 is a cell penetrant, potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor th at selectively kills cancer cells. JA2131 induces PARP1 hyper-PARylation and sensitizes cancer cells to radiation-induced DNA damage. JA2131 induces replication fork defects.
References	[1] Houl JH, et al. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 Dec 11;10(1):5654. DOI:10.1038/s41467-019-13508-4 [2] Brosey CA, et al. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 Aug;163:171-186. DOI:10.1016/j.pbiomolbio.2021.02.002

2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- Preparation Products And Raw materials

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