GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
| 中文名称 | GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 |
|---|---|
| 中文同义词 | NEUROMEDIN B肽;猪神经调节肽 B;神经介素 B;铃蟾肽相关肽;化合物NEUROMEDIN B;神经介素 B、NEUROMEDIN B;NEUROMEDIN B (PORCINE),BOMBESIN-LIKE多肽;猪神经介素B |
| 英文名称 | NEUROMEDIN B |
| 英文同义词 | NEUROMEDIN B (HUMAN, PORCINE, RAT);NEUROMEDIN B (HUMAN, PORCINE, RAT) ACOH 5H2O;NEUROMEDIN B, PORCINE;NEUROMEDIN B;H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2;GNLWATGHFM-NH2;GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2;GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O |
| CAS号 | 87096-84-2 |
| 分子式 | C52H73N15O12S |
| 分子量 | 1132.29 |
| EINECS号 | |
| 相关类别 | 生化试剂;多肽;其他生化试剂;标准品;目录多肽;Peptide;BombesinsCancer Research;Neuropeptides;Peptides for Cell Biology;Tumor Growth Regulation;Tumor Promotors;Neuromedins and related |
| Mol文件 | 87096-84-2.mol |
| 结构式 |  |
GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 性质
| 沸点 | 1697.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.337±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | H2O：12.5 mg/mL（11.04 mM；需要超声波） |
| 酸度系数(pKa) | 13.16±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 生物来源 | rabbit |
| 水溶解性 | Soluble to 1 mg/ml in water |
| 序列 | H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2 |
| InChIKey | YPFNACALNKVZNK-UHFFFAOYSA-N |
| SMILES | CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2cnc[nH]2)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CN)C(C)O)C(N)=O |
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Human Endogenous Metabolite
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Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC 50 ) is only 5% of BN (EC 50 of BN/EC 50 of NMB) and about 10% of GRP (EC 50 of GRP/ EC 50 of NMB).
Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED 50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-P0241 | GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 Neuromedin B | 87096-84-2 | 1mg | 800元 |
| 2025/12/22 | HY-P0241 | GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 Neuromedin B | 87096-84-2 | 5mg | 2000元 |