- Ethyl (2S)-2-bromopropanoate
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- $122.00 / 1KG
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2025-09-25
- CAS:535-11-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | Ethyl 2-bromopropionate Basic information |
| | Ethyl 2-bromopropionate Chemical Properties |
| Melting point | <25 °C | | Boiling point | 156-160 °C (lit.) | | density | 1.394 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.446(lit.) | | Fp | 125 °F | | storage temp. | Store below +30°C. | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Liquid | | color | Clear colorless to very slightly yellow | | Water Solubility | Immiscible | | Merck | 14,3772 | | BRN | 773920 | | Dielectric constant | 9.3000000000000007 | | Stability: | Corrosive | | InChI | 1S/C5H9BrO2/c1-3-8-5(7)4(2)6/h4H,3H2,1-2H3 | | InChIKey | ARFLASKVLJTEJD-UHFFFAOYSA-N | | SMILES | CCOC(=O)C(C)Br | | CAS DataBase Reference | 535-11-5(CAS DataBase Reference) | | NIST Chemistry Reference | Propanoic acid, 2-bromo-, ethyl ester(535-11-5) | | EPA Substance Registry System | Propanoic acid, 2-bromo-, ethyl ester (535-11-5) |
| Hazard Codes | C,Xn | | Risk Statements | 10-34-36/37/38-20/22 | | Safety Statements | 16-26-36/37/39-45-37/39 | | RIDADR | UN 2920 8/PG 2 | | WGK Germany | 3 | | RTECS | UA2451730 | | F | 8-19 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29159080 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 3
Skin Corr. 1B | | Toxicity | LD50 orally in Rabbit: 281 mg/kg |
| | Ethyl 2-bromopropionate Usage And Synthesis |
| Chemical Properties | clear colorless to very slightly yellow liquid | | Uses | Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals. | | Uses | Its an important organic intermediate can be used in agrochemical, pharmaceutical synthesis and dyestuff field. | | Synthesis | General procedure for the synthesis of ethyl 2-bromopropionate from ethanol and 2-bromopropionic acid: (a) (ii) A solution of Et2O (5 mL) in 1 M HCl was added to a solution of EtOH (200 mL) in 2-bromopropionic acid (25 g). The reaction mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator to give a yellow oily product, ethyl 2-bromopropionate, in a yield of 20.4 g (about 75% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 4.36 (q, J = 7.00 Hz, 1H), 4.24 (qd, J = 7.00 Hz, 2.69 Hz, 2H), 1.83 (d, J = 7.08 Hz, 3H), 1.31 (t, J = 7.20 Hz, 3H). | | Purification Methods | Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beils | | References | [1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 304 - 309
[2] Patent: WO2010/86613, 2010, A1. Location in patent: Page/Page column 39
[3] Journal of the American Chemical Society, 2014, vol. 136, # 50, p. 17662 - 17668
[4] Justus Liebigs Annalen der Chemie, 1879, vol. 197, p. 13
[5] Monatshefte fuer Chemie, 1881, vol. 2, p. 546 |
| | Ethyl 2-bromopropionate Preparation Products And Raw materials |
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