LMP744

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:LMP744；MJ-III65;NSC706744
CAS:308246-52-8
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Labnetwork lnc.
Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Products Intro: Product Name:6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
CAS:308246-52-8
Purity:95% Package:100g; 1kg Remarks:LN03262961
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:LMP744 (MJ-III65; NSC706744)
CAS:308246-52-8
Purity:98% Package:5mg Remarks:V5185
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:LMP744
CAS:308246-52-8
Package:50mg;957USD|25mg;736USD|100mg;1440USD
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:LMP744
CAS:308246-52-8
Package:50mg;957USD|25mg;736USD|100mg;1440USD

LMP744 manufacturers

  • LMP744
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  • $957.00 / 50mg
  • 2026-04-14
  • CAS:308246-52-8
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
  • LMP744
  • LMP744 pictures
  • $957.00 / 50mg
  • 2025-08-22
  • CAS:308246-52-8
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
LMP744 Basic information
Product Name:LMP744
Synonyms:LMP744;NSC-706744;6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4,5:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione(WXG02929);5H-[1,3]Dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-;6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;LMP744 (MJ-III65;LMP744,LMP-744;20-{3-[(2-hydroxyethyl)amino]propyl}-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,1?.0?,?.013,1?]icosa-1(12),2(10),3,8,13(18),14,16-heptaene-11,19-dione
CAS:308246-52-8
MF:C24H24N2O7
MW:452.45656
EINECS:
Product Categories:
Mol File:308246-52-8.mol
LMP744 Structure
LMP744 Chemical Properties
Melting point 231-234 °C
Boiling point 748.1±60.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka14.79±0.10(Predicted)
form Solid
color Brown to dark brown
Safety Information
MSDS Information
LMP744 Usage And Synthesis
UsesLMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
in vivo

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

Animal Model:Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
Dosage:10, 25, or 50 mg/kg/week, 4 weeks
Administration:I.V. push via tail vein
Result:Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
IC 50Top1
References[1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 2007 Nov 1;67(21):10397-405. DOI:10.1158/0008-5472.CAN-07-0938
LMP744 Preparation Products And Raw materials
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