|
|
| | 2-Amino-5-chlorobenzophenone Basic information |
| | 2-Amino-5-chlorobenzophenone Chemical Properties |
| Melting point | 96-98 °C (lit.) | | Boiling point | 207 °C | | density | 1.33 | | vapor pressure | 0-1Pa at 20-25℃ | | refractive index | 1.6000 (estimate) | | Fp | 211 °C | | storage temp. | Store below +30°C. | | solubility | Solubility in methanol gives very faint turbidity. Soluble in DMSO. | | form | Crystalline Powder | | pka | 0.06±0.10(Predicted) | | color | Yellow | | BRN | 475640 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | 1S/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2 | | InChIKey | ZUWXHHBROGLWNH-UHFFFAOYSA-N | | SMILES | Nc1ccc(Cl)cc1C(=O)c2ccccc2 | | LogP | 3.16 at 21℃ and pH7 | | CAS DataBase Reference | 719-59-5(CAS DataBase Reference) | | NIST Chemistry Reference | Benzophenone, 2-amino-5-chloro-(719-59-5) | | EPA Substance Registry System | Methanone, (2-amino-5-chlorophenyl)phenyl- (719-59-5) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22-20/21/22 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | PC4933500 | | TSCA | TSCA listed | | HS Code | 29223900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1 | | Toxicity | LD50 orally in Rabbit: 10000 mg/kg |
| | 2-Amino-5-chlorobenzophenone Usage And Synthesis |
| Chemical Properties | yellow powder | | Uses | A metabolite of Diazepam; it had a much weaker anticonvulsant effect. | | Uses | It is used in the heterocyclic syntheses based on the reactions of dimethyl acetylenedicarboxylate. | | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9 | | General Description | 2-Amino-5-chlorobenzophenone is a organic nonlinear optical material. | | Synthesis | (2) 10.0 g of intermediate (II) was added to a three-necked flask containing 50 mL of ethanol, 4.8 g of iron powder was added, and refluxed for 0.5 hours. Subsequently, 1 mL of 6 mol/L sulfuric acid solution was slowly added dropwise. After the dropwise addition, the reaction was continued to reflux for 1 hour. After the reaction was completed, the pH of the reaction solution was adjusted to 8 with NaOH solution and cooled to 50 °C. Add 0.2 g of activated carbon and reflux for 0.5 h. Perform hot filtration into a crystallization flask and cool the crystals. The crystals were washed with ethanol and dried to give 9.60 g of intermediate (III) in 95.1% yield, melting point 96.3-98.2 °C. | | References | [1] Journal of Chemical Research - Part S, 2002, # 12, p. 601 - 603
[2] Patent: CN108250091, 2018, A. Location in patent: Paragraph 0032; 0034; 0040
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 690 - 691
[4] Patent: CN106083621, 2016, A. Location in patent: Paragraph 0021-0025
[5] Patent: CN107935872, 2018, A. Location in patent: Paragraph 0034-0063; 0067-0074 |
| | 2-Amino-5-chlorobenzophenone Preparation Products And Raw materials |
|