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ShangHai AmK Pharmaceutical Technology Co., Ltd.
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Product Name:ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
CAS:139308-52-4
Purity:0.97 Package:1g,10g,100g
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| Company Name: |
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66028182 17714375163 |
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| Products Intro: |
Product Name:Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate
CAS:139308-52-4
Purity:95+% Package:1g;5g;10g
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| Company Name: |
SuZhou ShiYa Biopharmaceuticals, Inc.
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0512-0512-52358471 17715136450 |
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Product Name:3-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester
CAS:139308-52-4
Purity:>95% Package:1g;5g;10g;25g Remarks:B1-8560
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| | ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Basic information |
| Product Name: | ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate | | Synonyms: | ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate;3-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 3-bromo-1-methyl-, ethyl ester;ethyl 3-bromo-1-methyl-pyrazole-4-carboxylate | | CAS: | 139308-52-4 | | MF: | C7H9BrN2O2 | | MW: | 233.06 | | EINECS: | | | Product Categories: | | | Mol File: | 139308-52-4.mol |  |
| | ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties |
| Boiling point | 290.7±20.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -2.40±0.10(Predicted) |
| | ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Usage And Synthesis |
| Synthesis | To a solution of ethyl 3-bromopyrazole-4-carboxylate (5.6 g, 25.57 mmol) in DMF (200 ml) was added iodomethane (14.52 g, 102.28 mmol, 6.37 ml) and cesium carbonate (33.32 g, 102.28 mmol). The reaction mixture was stirred at 25°C for 12 hours. After completion of the reaction, the mixture was diluted with deionized water (1000 ml) and extracted with ethyl acetate (500 ml). The organic layer was subsequently washed with saturated brine (500 ml x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was initially purified (4 g) by preparative HPLC (alkaline conditions). Further purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10/1 to 5:1) afforded ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (1 g, yield: 16.8%) and ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate (2 g, yield: 33.6%), both as white solid. | | References | [1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 0506; 0936 |
| | ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials |
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