H-VAL-PRO-PRO-OH
| 中文名称 | H-VAL-PRO-PRO-OH |
|---|---|
| 中文同义词 | (2S)-1-[(2S)-1-[(2S)-2-AMINO-3-METHYLBUTANOYL]PYRROLIDINE-2-CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID;化合物H-VAL-PRO-PRO-OH;抑制剂三肽VPP |
| 英文名称 | H-VAL-PRO-PRO-OH |
| 英文同义词 | H-VAL-PRO-PRO-OH;(S)-1-((S)-1-((S)-2-AMino-3-Methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid;VPP Tripeptide;L-Proline, L-valyl-L-prolyl-;inhibit,Angiotensin Receptor,Inhibitor,H Val Pro Pro OH,HValProProOH |
| CAS号 | 58872-39-2 |
| 分子式 | C15H25N3O4 |
| 分子量 | 311.38 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 58872-39-2.mol |
| 结构式 |  |
H-VAL-PRO-PRO-OH 性质
| 沸点 | 566.4±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.274±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.42±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
H-Val-Pro-Pro-OH，是牛奶来源的脯氨酸肽衍生物，是血管紧张素 I 转化酶 (ACE) 的抑制剂，其IC50 为 9 μM。
IC50: 9 μM (ACE).
H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC 50 of 9 μM. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-114161 | H-Val-Pro-Pro-OH | 58872-39-2 | 5 mg | 350元 |
| 2025/05/22 | HY-114161 | H-Val-Pro-Pro-OH | 58872-39-2 | 10 mg | 550元 |