- 2-Amino-3-fluoropyridine
-
- $5.00 / 1KG
-
2025-09-25
- CAS:21717-95-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-Amino-3-fluoropyridine Basic information |
| | 2-Amino-3-fluoropyridine Chemical Properties |
| Melting point | 41-45 °C | | Boiling point | 110°C/65mmHg(lit.) | | density | 1.257±0.06 g/cm3(Predicted) | | Fp | 90℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.95±0.36(Predicted) | | form | powder to crystal | | color | White to Gray to Brown | | InChI | InChI=1S/C5H5FN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8) | | InChIKey | WWEINXQNCAWBPD-UHFFFAOYSA-N | | SMILES | C1(N)=NC=CC=C1F | | CAS DataBase Reference | 21717-95-3 |
| Hazard Codes | T,Xi,Xn | | Risk Statements | 36/37/38-36-22 | | Safety Statements | 26-36/37/39 | | RIDADR | UN2811 | | WGK Germany | 3 | | HazardClass | 6.1 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 2-Amino-3-fluoropyridine Usage And Synthesis |
| Chemical Properties | Light yellow Cryst | | Uses | 2-Amino-3-fluoropyridine is a reagent used in the synthesis of potent sigma-1 receptor antagonists and mu opioid receptor agonists for the treatment of neuropathic pain. | | Synthesis | General procedure for the synthesis of 2-amino-3-fluoro-5-chloropyridine from 2-amino-3-fluoro-5-chloropyridine: 2-amino-3-fluoro-5-chloropyridine (50 g, 0.341 mol) and methanol (600 mL) were added to a 1000 mL single-necked round-bottomed flask, and stirred until completely dissolved. Ammonia (50 mL) and Pd/C catalyst (2.5 g, 23.5 mmol) were then added. The catalytic hydrogenation reaction was carried out under hydrogen atmosphere until the reaction was complete. After completion of the reaction, the Pd/C catalyst was removed by filtration and the filter cake was washed with methanol. The filtrate and washings were combined and concentrated under reduced pressure to give a white solid crude. The crude was dissolved in water (200 mL x 4) and extracted with ethyl acetate. The organic layer was collected, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the concentrate was pulped with a small amount of petroleum ether and filtered to give 34.50 g of white crystal product in 90.20% yield. | | References | [1] Patent: CN105669539, 2016, A. Location in patent: Paragraph 0061; 0062; 0063 |
| | 2-Amino-3-fluoropyridine Preparation Products And Raw materials |
|