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| | LYN PEPTIDE INHIBITOR Basic information |
| Product Name: | LYN PEPTIDE INHIBITOR | | Synonyms: | LYN PEPTIDE INHIBITOR;M.W. 2370.91 C115H184N30O24;L-Prolinamide, N-(1-oxooctadecyl)-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl- | | CAS: | 222018-18-0 | | MF: | C115H184N30O24 | | MW: | 2370.92 | | EINECS: | | | Product Categories: | Protein Kinase | | Mol File: | 222018-18-0.mol |  |
| | LYN PEPTIDE INHIBITOR Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | Sequence | Stearoyl-Tyr-Gly-Tyr-Arg-Leu-Arg-Arg-Lys-Trp-Glu-Glu-Lys-Ile-Pro-Asn-Pro-NH2 |
| | LYN PEPTIDE INHIBITOR Usage And Synthesis |
| Uses | Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase toβc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders[1]. | | IC 50 | IL-5; IL-3 | | References | [1] T Adachi, et al. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501. PMID:9973406
[2] T Adachi, et al. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J Immunol. 1999 Jul 15;163(2):939-46. PMID:10395690 |
| | LYN PEPTIDE INHIBITOR Preparation Products And Raw materials |
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