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| | 3-Aminobenzeneboronic acid Basic information |
| | 3-Aminobenzeneboronic acid Chemical Properties |
| Melting point | 225 °C | | Boiling point | 376.0±44.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | form | powder or crystals | | pka | pK1: 4.46;pK2: 8.81 (25°C) | | color | Off-white to light brown | | Water Solubility | Soluble in water (partly miscible). | | InChI | InChI=1S/C6H8BNO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H,8H2 | | InChIKey | JMZFEHDNIAQMNB-UHFFFAOYSA-N | | SMILES | B(C1=CC=CC(N)=C1)(O)O | | CAS DataBase Reference | 30418-59-8(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36/37/39-37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29310095 | | Storage Class | 11 - Combustible Solids |
| | 3-Aminobenzeneboronic acid Usage And Synthesis |
| Chemical Properties | hexagonal plates | | Uses | 3-Aminobenzeneboronic acid is a boronic acid with potential use for biochemical research,it ie also used for suzuki reaction. | | Uses | 3-Aminobenzeneboronic acid is used as an organic chemical synthesis intermediate. It is a boronic acid with potential use for biochemical research. | | Synthesis | General method: 3-nitrophenylboronic acid (1 eq.), hexafluoroisopropanol (HFIP, 10 eq.) and iron powder (5 eq.) were added to the reaction tube and mixed. Subsequently, 2N aqueous hydrochloric acid solution was added dropwise to the reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes and then neutralized with saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was extracted three times with saturated aqueous sodium bicarbonate solution and combined. The organic layer was subsequently washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure. Finally, the crude product was purified by silica gel column chromatography to afford the target compound 3-aminophenylboronic acid. | | References | [1] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3646 - 3649
[2] Journal of the American Chemical Society, 1932, vol. 54, p. 4415,4418
[3] Journal of Organic Chemistry, 1937, vol. 2, p. 522,533
[4] Journal of the American Chemical Society, 1931, vol. 53, p. 713
[5] Patent: US2007/209123, 2007, A1. Location in patent: Page/Page column 7 |
| | 3-Aminobenzeneboronic acid Preparation Products And Raw materials |
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