3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide

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3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide manufacturers

  • OXSI-2
  • OXSI-2 pictures
  • $667.00
  • 2026-08-30
  • CAS:622387-85-3
  • Purity:
  • Supply Ability: 10g
3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide Basic information
Product Name:3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide
Synonyms:Syk Inhibitor;OXSI 2;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation;3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide
CAS:622387-85-3
MF:C18H15N3O3S
MW:353.4
EINECS:
Product Categories:pharmacetical;Spleen Tyrosine Kinase Inhibitor
Mol File:622387-85-3.mol
3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide Structure
3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide Chemical Properties
density 1.490±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Orange powder solid.
pka9.594±0.20(predicted)
color Light yellow to brown
Sensitive Light Sensitive
InChI1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)
InChIKeyMLKHXLFEYOOYEY-UHFFFAOYSA-N
SMILES[S](=O)(=O)(N)c1cc2c(cc1)NC(=O)C2=Cc3c4c([n](c3)C)cccc4
Safety Information
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide Usage And Synthesis
DescriptionSpleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.
UsesOXSI 2 is a Syk selective inhibitor.
References[1] PAUL J. COX  et al. et al. Potent Small Molecule Inhibitors of Spleen Tyrosine Kinase (Syk).[J]. ChemInform, 2003, 34 51. DOI: 10.1002/chin.200351119
[2] KAMALA BHAVARAJU . Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets[J]. European journal of pharmacology, 2008, 580 3: Pages 285-290. DOI: 10.1016/j.ejphar.2007.11.009
3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide Preparation Products And Raw materials
Tag:3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide(622387-85-3) Related Product Information
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