- 7-Chloro-1-tetralone
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- $17.00 / 10g
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2026-01-23
- CAS:26673-32-5
- Min. Order: 10g
- Purity: 0.98
- Supply Ability: 25kg
- 7-Chloro-1-tetralone
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- $0.00 / 1KG
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2022-01-04
- CAS:26673-32-5
- Min. Order: 1g
- Purity: 98%minHPLC
- Supply Ability: 100kgs/month
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| | 7-Chloro-1-tetralone Basic information | | Uses |
| Product Name: | 7-Chloro-1-tetralone | | Synonyms: | 7-chloro-3,4-dihydronaphthalen-1(2H)-one;7-chloro-3;7-chloro-1,2,3,4-tetrahydronaphthalen-1-one;1(2H)-Naphthalenone, 7-chloro-3,4-dihydro-;7-CHLORO-1-TETRALONE;7-CHLORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;7-Chloro-α-Tetralone;7-Chloro-3,4-dihydro-2H-phthalen-1-one | | CAS: | 26673-32-5 | | MF: | C10H9ClO | | MW: | 180.63 | | EINECS: | 808-026-1 | | Product Categories: | | | Mol File: | 26673-32-5.mol |  |
| | 7-Chloro-1-tetralone Chemical Properties |
| Melting point | 93.0 to 97.0 °C | | Boiling point | 115°C/0.3mmHg(lit.) | | density | 1.248±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Toluene | | form | powder to crystal | | color | White to Yellow to Green | | λmax | 305nm(MeOH)(lit.) | | InChI | InChI=1S/C10H9ClO/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6H,1-3H2 | | InChIKey | IIMAYXKDBHTQHC-UHFFFAOYSA-N | | SMILES | C1(=O)C2=C(C=CC(Cl)=C2)CCC1 | | CAS DataBase Reference | 26673-32-5 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 3 | | HS Code | 2914790090 | | Storage Class | 11 - Combustible Solids |
| | 7-Chloro-1-tetralone Usage And Synthesis |
| Uses | 7-Chloro-1-tetralone (cas# 26673-32-5) is a useful research chemical. | | Chemical Properties | Pale yellow to white crystalline powder | | Synthesis | General procedure for the synthesis of 7-chloro-3,4-dihydro-2H-1-naphthalenone from 4-(4-chlorophenyl)butyric acid: polyphosphoric acid (20 g, excess) was placed in a beaker and heated to 90 °C. 4-(4-Chlorophenyl)butyric acid (3 g, 17 mmol) was added in batches. The reaction mixture was stirred for 5 minutes and then polyphosphoric acid (20 g, excess) was added and continued to be heated at 90°C for 5 minutes. The resulting thick orange viscous oil was cooled to 60 °C, followed by the slow addition of water. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water, 1N NaOH solution and water, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give a white solid product (2.5 g, 81% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.12-2.18 (m, 2H), 2.67 (t, J = 6.8 Hz, 2H), 2.95 (t, J = 6.8 Hz, 2H), 7.22 (d, J = 8.0 Hz, 1H), 7.42 (dd, J = 10.2, 2.4 Hz, 1H), 7.85 (d , J = 2.4 Hz, 1H). | | References | [1] Angewandte Chemie - International Edition, 2017, vol. 56, # 41, p. 12476 - 12480
[2] Angew. Chem., 2017, vol. 129, p. 12650 - 12654,5
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6768 - 6781
[4] Patent: WO2017/150904, 2017, A1. Location in patent: Paragraph 312-314
[5] Synthetic Communications, 1991, vol. 21, # 8-9, p. 981 - 987 |
| | 7-Chloro-1-tetralone Preparation Products And Raw materials |
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