- (R,S)-Anatabine
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- $39.00 / 10mg
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2026-03-13
- CAS:2743-90-0
- Min. Order:
- Purity: 98.95%
- Supply Ability: 10g
- (R,S)-Anatabine
-
- $39.00 / 10mg
-
2026-03-13
- CAS:2743-90-0
- Min. Order:
- Purity: 98.95%
- Supply Ability: 10g
- (R,S)-ANATABINE
-
- $0.00 / 1g
-
2019-12-23
- CAS:2743-90-0
- Min. Order: 1g
- Purity: 95%min
- Supply Ability: 20kg/month
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| | (R,S)-ANATABINE Basic information |
| Product Name: | (R,S)-ANATABINE | | Synonyms: | (R,S)-ANATABINE;ANATABINE, (+/-)-(RG);(+/-)-Anatabine, 3-(1,2,3,6-Tetrahydropyridin-2-yl)pyridine, 2-(Pyridin-3-yl)-1,2,3,6-tetrahydropyridine;Anatabine, froM Nicotiana tabacuM L.;D,L-ANATABINE;Anatabine, 97%, from Nicotiana tabacum L.;1,2,3,6-Tetrahydro-2,3'-bipyridine 98%;Nicotine USP RC A | | CAS: | 2743-90-0 | | MF: | C10H12N2 | | MW: | 160.22 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Metabolites & Impurities;Metabolites;Nicotine Derivatives | | Mol File: | 2743-90-0.mol |  |
| | (R,S)-ANATABINE Chemical Properties |
| Boiling point | 136 | | density | 1.045±0.06 g/cm3(Predicted) | | storage temp. | Amber Vial, Refrigerator, Under Inert Atmosphere | | solubility | ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide | | pka | 8.84±0.40(Predicted) | | form | solution in ethanol. | | color | Light yellow to yellow | | Stability: | Hygroscopic, Light Sensitive | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h1-4,6,8,10,12H,5,7H2 | | InChIKey | SOPPBXUYQGUQHE-UHFFFAOYSA-N | | SMILES | C1(C2=CC=CN=C2)NCC=CC1 | | CAS DataBase Reference | 2743-90-0 |
| Risk Statements | 25-36 | | Safety Statements | 24/25 | | RIDADR | 2810 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 29399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2 |
| | (R,S)-ANATABINE Usage And Synthesis |
| Description | (R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation. | | Chemical Properties | Light Yellow Oil | | Uses | A nicotine metabolite | | Uses | A nicotine (N412420) metabolite. | | Uses | (R,S)-Anatabine is a metabolite of Nicotine (N412420). | | in vitro | anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1]. | | in vivo | in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1]. | | references | [1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391. |
| | (R,S)-ANATABINE Preparation Products And Raw materials |
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