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| | 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Basic information |
| Product Name: | 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione | | Synonyms: | 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione;4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-;ZIM;ZIM, 10 mM in DMSO | | CAS: | 301298-87-3 | | MF: | C20H19N3O3 | | MW: | 349.38 | | EINECS: | | | Product Categories: | | | Mol File: | 301298-87-3.mol |  |
| | 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Chemical Properties |
| Boiling point | 484.5±55.0 °C(Predicted) | | density | 1.390±0.06 g/cm3(Predicted) | | pka | 1.40±0.65(Predicted) | | form | Solid | | color | White to off-white |
| | 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Usage And Synthesis |
| Uses | ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research[1]. | | in vivo | ZIM (i.p., 12, 24 and 48 mg/kg) can effectively reduce the frequency of chromosome micronucleus at all doses at 24 and 72 h in adult male Swiss mice, and has certain chemoprophylaxis effect, and the percentage of damage reduction ranges from 38.36 to 83.26%[1].
ZIM (i.p., 12, 24 and 48 mg/kg) reduces the frequency of cisplatin-CIS and doxorubicin-DOX-induced liver and kidney cell death. At 12, 24 and 48 mg/kg dosages, the percentage of liver damage reduction in CIS group are 79.27, 75.20 and 52.84%, and that in DOX group are 62.06, 59.44 and 77.80%, respectively. The reduction percentages of kidney injury in CIS group are 45.29, 36.09 and 41.61%, and those in DOX group are 28.00, 21.41 and 30.82%, respectively[1].
| | References | [1] Rodrigo Juliano Oliveira, et al. ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics. Chem Res Toxicol. 2022 Dec 22. DOI:10.1021/acs.chemrestox.2c00275 |
| | 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Preparation Products And Raw materials |
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