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| | METHYL 5-BROMO-2-FUROATE Basic information |
| Product Name: | METHYL 5-BROMO-2-FUROATE | | Synonyms: | RARECHEM AL BF 0601;BUTTPARK 94\04-07;methyl 5-bromo-2-furoate 97%;METHYL-2-BROMOFURAN-CARBOXYLATE;METHYL 5-BROMO-2-FUROATE;Methyl 5-bromo-2-furoate,98%;5-BROMO-2-FUROIC ACID METHYL ESTER;5-BROMO-FURAN-2-CARBOXYLIC ACID METHYL ESTER | | CAS: | 2527-99-3 | | MF: | C6H5BrO3 | | MW: | 205.01 | | EINECS: | | | Product Categories: | | | Mol File: | 2527-99-3.mol |  |
| | METHYL 5-BROMO-2-FUROATE Chemical Properties |
| Melting point | 63-68 °C | | Boiling point | 80°C/0.7mmHg(lit.) | | density | 1.623±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Soluble), DMSO (Slightly) | | form | Crystalline Powder | | color | White to slightly yellow | | Water Solubility | Slightly soluble in water. | | λmax | 264nm(EtOH)(lit.) | | InChIKey | FBPIDMAELBIRLE-UHFFFAOYSA-N | | CAS DataBase Reference | 2527-99-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | HazardClass | IRRITANT | | HS Code | 29321900 |
| | METHYL 5-BROMO-2-FUROATE Usage And Synthesis |
| Chemical Properties | White to slightly yellow crystalline powder | | Uses | It is used in the preparation of hydroquinone bis(2-carbomethoxy-5-furyl ether). | | Synthesis | General procedure for the synthesis of methyl 5-bromofuran-2-carboxylate from methanol and 5-bromo-2-furoic acid: 5-bromo-2-furoic acid (950 mg, 5.00 mmol) was accurately weighed and dissolved in 10 mL of methanol, and 2 mL of sulfoxide chloride (SOCl2) was added slowly and dropwise. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The residue was dissolved in an appropriate amount of toluene and this dissolution and evaporation process was repeated three times to give the intermediate 5-bromo-2-furoic acid methyl ester in 100% yield. | | References | [1] Patent: CN103992311, 2017, B. Location in patent: Paragraph 0103; 0104; 0105; 0106; 0123; 0124; 0125
[2] Organic Letters, 2012, vol. 14, # 22, p. 5644 - 5647
[3] Patent: CN106977476, 2017, A. Location in patent: Paragraph 0103-0105
[4] Patent: WO2015/159103, 2015, A1. Location in patent: Page/Page column 33; 34; 37
[5] Patent: WO2015/1024, 2015, A1. Location in patent: Page/Page column 65 |
| | METHYL 5-BROMO-2-FUROATE Preparation Products And Raw materials |
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