1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)

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1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) Basic information
Product Name:1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)
Synonyms:1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)
CAS:428506-51-8
MF:C42H80ClNO4
MW:698.56
EINECS:
Product Categories:
Mol File:428506-51-8.mol
1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) Structure
1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) Chemical Properties
solubility DMF: Slightly soluble; DMSO: Slightly soluble; Ethanol: 20 mg/ml
form A solid
Safety Information
MSDS Information
1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) Usage And Synthesis
Description1,2-Dioleoyl-3(S)-trimethylammoniumpropane (S-DOTAP) is a cationic lipid and the less immunologically active isomer of DOTAP .1,2 Lipoplexes containing S-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells.1 Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in S-DOTAP-containing liposomes decrease tumor size but do not induce IFN-γ production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) in a murine cervical cancer model.2
Uses1,2-Dioleoyl-3(S)-trimethylammoniumpropane chloride is a biochemical reagent.
References1. Terp, M.C., Bauer, F., Sugimoto, Y., et al. Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro Int. J. Pharm. 430(1-2),328-334(2012).
2. Vasievich, E.A., Chen, W., and Huang, L. Enantiospecific adjuvant activity of cationic lipid DOTAP in cancer vaccine Cancer Immunol. Immunother. 60(5),629-638(2011).
1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) Preparation Products And Raw materials
Tag:1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)(428506-51-8) Related Product Information
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