| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
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| | ANTI-HEAT SHOCK PROTEIN 27 Basic information |
| Product Name: | ANTI-HEAT SHOCK PROTEIN 27 | | Synonyms: | Anti-Heat Shock Protein 27 antibody produced in rabbit;Monoclonal Anti-HSPB1 antibody produced in mouse;Anti-HSPB1 (AB1) antibody produced in rabbit;Anti-HSPB1 (AB2) antibody produced in rabbit;ANTI-HEAT SHOCK PROTEIN 27 RABBIT PAB;ANTI-HEAT SHOCK PROTEIN 27;ANTI-HEAT SHOCK PROTEIN 27 (AB-1), HUMAN;ANTI-HEAT SHOCK PROTEIN 27, HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HEAT SHOCK PROTEIN 27 Structure]() |
| | ANTI-HEAT SHOCK PROTEIN 27 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | ANTI-HEAT SHOCK PROTEIN 27 Usage And Synthesis |
| Uses | Anti-He at Shock Protein 27 antibody produced in rabbit may be used in immunoblotting and immunofluorescence. | | Biological Activity | He at shock protein 27 (HSP27) accumulates in cells exposed to a short period of hyperthermia and contributes to the development of a transient state of thermotolerance. HSP27 can inhibit actin polymerization, thus modulating actin dynamics during stress. It is known to guard against apoptotic cell death activated by several stimuli, such as Fas ligand hyperthermia, oxidative stress and cytotoxic drugs. It can hinder the mitochondrial pathway of caspase-induced cell death by acting as a negative regulator of cytochrome c-dependent activation of caspase-3. The synthesis of HSP27 is stimulated by various cytokines, growth factors, hormones and chemicals. HSP27 shows a rapid phosphorylation, following exposure to stress stimuli. HSP27 is expressed in the cytoplasm and colocalizes to the nucleus upon stress stimuli. Mutation on this HSP27 gene is associated with Charcot-Marie-Tooth disease. |
| | ANTI-HEAT SHOCK PROTEIN 27 Preparation Products And Raw materials |
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