(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol

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(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol Basic information
Product Name:(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol
Synonyms:(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol;Benzaldehyde, 2-hydroxy-3-methoxy-, 2-(2,5-dihydro-6-methyl-5-oxo-1,2,4-triazin-3-yl)hydrazone;Antibacterial agent 227
CAS:301304-67-6
MF:C12H13N5O3
MW:275.26
EINECS:
Product Categories:
Mol File:301304-67-6.mol
(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol Structure
(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol Chemical Properties
density 1.43±0.1 g/cm3(Predicted)
pka8.26±0.40(Predicted)
Safety Information
MSDS Information
(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol Usage And Synthesis
UsesAntibacterial agent 227 (Compd 29) is a SerRS (Seryl-tRNA synthetase) inhibitor. Antibacterial agent 227 has a significant inhibitory effect on the growth of planktonic and biofilm culture of Staphylococcus aureus 25923 with MIC (minimum inhibitory concentration) value of 32μg/ml. Antibacterial agent 227 can be proposed as effective antiseptic toward multidrug-resistant biofilm-forming S. aureus isolates[1].
References[1] Volynets GP, et al. Identification of novel antistaphylococcal hit compounds. J Antibiot (Tokyo). 2024 Jun 25. DOI:10.1038/s41429-024-00752-0
(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol Preparation Products And Raw materials
Tag:(E)-3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazinyl)-6-methyl-1,2,4-triazin-5-ol(301304-67-6) Related Product Information
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