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| | BOC-3-AMINO-4-METHYLBENZOIC ACID Basic information |
| Product Name: | BOC-3-AMINO-4-METHYLBENZOIC ACID | | Synonyms: | BOC-3-AMINO-4-METHYLBENZOIC ACID;BOC-(3)ATL(4)-OH;BOC-(3)ABZ(4-ME)-OH;3-[(tert-butyloxycarbonyl)aMino]-4-Methylbenzoic acid;3--4-Methylbenzoicacid 231958-04-6;3-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-methylbenzoic acid;N-T-BUTOXYCARBONYL-3-AMINO-4-METHYL-BENZOIC ACID;N-T-BUTOXYCARBONYL-3-AMINO-4-TOLUIC ACID | | CAS: | 231958-04-6 | | MF: | C13H17NO4 | | MW: | 251.28 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | BOC-3-AMINO-4-METHYLBENZOIC ACID Chemical Properties |
| Boiling point | 354.3±35.0 °C(Predicted) | | density | 1.212±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.32±0.10(Predicted) | | Appearance | White to off-white Solid |
| | BOC-3-AMINO-4-METHYLBENZOIC ACID Usage And Synthesis |
| Synthesis | To a mixed solution of 3-amino-4-methylbenzoic acid (2.0 g, 13.2 mmol) in water (25 mL) and 1 N sodium hydroxide (25 mL) was added di-tert-butyl dicarbonate (4.3 g, 19.8 mmol). The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was extracted by partitioning with ethyl acetate and 5% aqueous citric acid. The organic layer was separated, washed sequentially with water and saturated saline, and then dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give 3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid as a pink solid (3.3 g, quantitative yield). | | References | [1] Patent: US2012/142708, 2012, A1. Location in patent: Page/Page column 23
[2] Patent: WO2005/42537, 2005, A1. Location in patent: Page/Page column 46; 47
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 3700 - 3705
[4] European Journal of Organic Chemistry, 2001, # 2, p. 311 - 322
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 4 - 16 |
| | BOC-3-AMINO-4-METHYLBENZOIC ACID Preparation Products And Raw materials |
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