4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine

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4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine Basic information
Product Name:4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine
Synonyms:4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine;WAY-327111;Morpholine, 4-[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]-;EP2 receptor antagonist-2;EP2 receptor antagonist-2, 10 mM in DMSO
CAS:615273-95-5
MF:C15H14F3N3O
MW:309.29
EINECS:
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Mol File:615273-95-5.mol
4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine Structure
4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine Chemical Properties
Boiling point 451.8±55.0 °C(Predicted)
density 1.299±0.06 g/cm3(Predicted)
form Solid
pka1.48±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine Usage And Synthesis
UsesEP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA)[1].
IC 50EP
References[1] Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707. DOI:10.1021/acschemneuro.7b00486
4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine Preparation Products And Raw materials
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