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| | (4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone Basic information |
| Product Name: | (4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone | | Synonyms: | (4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone;NPD10084;Methanone, (4-methoxy-1H-indol-2-yl)(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)- | | CAS: | 1040706-91-9 | | MF: | C21H19N3O2 | | MW: | 345.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1040706-91-9.mol | ![(4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone Structure](CAS/20180719/GIF/1040706-91-9.gif) |
| | (4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone Chemical Properties |
| Boiling point | 640.1±55.0 °C(Predicted) | | density | 1.364±0.06 g/cm3(Predicted) | | form | Solid | | pka | 15.92±0.30(Predicted) | | color | Off-white to light yellow |
| | (4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone Usage And Synthesis |
| Uses | NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1]. | | References | [1] Nagasawa I, et al. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol. 2020 Feb 20;27(2):186-196.e4. DOI:10.1016/j.chembiol.2019.11.010 |
| | (4-methoxy-1H-indol-2-yl)-(1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)methanone Preparation Products And Raw materials |
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