| Company Name: |
Alinda Chemical Ltd.
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| Tel: |
+7 (495) 672-17-08 |
| Email: |
sale@alinda.ru |
| Products Intro: |
CAS:62289-81-0
Package:1mg Remarks:C10H8N2OS
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N-pyridin-3-ylthiophene-2-carboxamide manufacturers
- SW106065
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- $31.00 / 1mg
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2024-11-19
- CAS:62289-81-0
- Min. Order:
- Purity: 99.96%
- Supply Ability: 10g
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| | N-pyridin-3-ylthiophene-2-carboxamide Basic information |
| Product Name: | N-pyridin-3-ylthiophene-2-carboxamide | | Synonyms: | N-pyridin-3-ylthiophene-2-carboxamide;SW-106065;2-Thiophenecarboxamide, N-3-pyridinyl-;cell,SW 106065,cdk4,Inhibitor,MPNST,cycle,ATP,anticancer,cdk6,cyclin,SW106065,Apoptosis,inhibit;SW106065, 10 mM in DMSO;MPNST Inhibitor, Cpd21 | | CAS: | 62289-81-0 | | MF: | C10H8N2OS | | MW: | 204.25 | | EINECS: | | | Product Categories: | | | Mol File: | 62289-81-0.mol |  |
| | N-pyridin-3-ylthiophene-2-carboxamide Chemical Properties |
| Boiling point | 270.8±15.0 °C(Predicted) | | density | 1.352±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mg/mL (489.60 mM) | | pka | 12.39±0.70(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | N-pyridin-3-ylthiophene-2-carboxamide Usage And Synthesis |
| Uses | SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). SW106065 inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research[1]. | | Biological Activity | Cell permeable: yes', 'Reversible: yes | | in vivo | SW106065 (Cpd21; 40 mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development[1]. | Animal Model: | NCR-nu/nu female mice (6-7 week old) injected with MPNST cells[1] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection; twice per day for 4 weeks | | Result: | Reduced MPNST burden in a mouse allograft model.
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| | References | [1] Vincent Chau, et al. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 2014 Jan 15;74(2):586-97. DOI:10.1158/0008-5472.CAN-13-1934 |
| | N-pyridin-3-ylthiophene-2-carboxamide Preparation Products And Raw materials |
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