| Company Name: |
Wuhan Chemstan Biotechnology Co., Ltd.
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| Tel: |
027-65317797 15926423062 |
| Email: |
422450190@qq.com |
| Products Intro: |
Product Name:Human FLT1 Protein, His Tag
Purity:>90% as determined by SDS-PAGE Package:50μg, 100μg
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| Company Name: |
Biolab Reagents
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| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Products Intro: |
Product Name:VEGFR1
Purity:95% SDS-PAGE Package:1mg;100ug
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| Company Name: |
ACROBiosystems
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| Tel: |
13121935750 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Products Intro: |
Product Name:VEGFR1
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| Product Name: | EMRK2, HUMAN | | Synonyms: | FLT-1;FLT-1, HUMAN;FLT-1, HUMAN, 17AA NEAR CT;EMRK2;EMRK2, HUMAN;VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1, HUMAN;VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1, HUMAN, 17AA NEAR CT;VEGF-R1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | protein kinase | | Mol File: | Mol File | ![EMRK2, HUMAN Structure]() |
| | EMRK2, HUMAN Chemical Properties |
| storage temp. | -70°C | | form | buffered aqueous glycerol solution | | biological source | human | | Specific Activity | 30-40nmol/min·mg |
| Hazard Codes | T | | Risk Statements | 61 | | Safety Statements | 53-45 | | WGK Germany | 1 | | HS Code | 3504009000 | | Storage Class | 10 - Combustible liquids |
| | EMRK2, HUMAN Usage And Synthesis |
| Uses | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | | Biological Activity | FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is implicated in angiogenesis in tumors, which plays a key role in tumorigenesis, invasion and metastasis of tumors, especially the malignant ones. In human circulation, angiogenesis is balanced by soluble FLT1 (sFLT1) and VEGF. An imbalance leads to multiple conditions such as pre-eclampsia. sFLT1 plays an essential role in the angiogenesis of placenta. An overexpression of this protein in placenta is associated with prenatal arsenic exposure and thus, reduced birth weight. | | Description | Soluble FLT1 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide containing 687 amino acids and having a molecular mass of 96 kDa. The soluble receptor protein contains only the first 6 extracellular domains, which contain all the information necessary for binding of VEGF.
The FLT1 is purified by proprietary chromatographic techniques. | | Source | Insect Cells | | Background | Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA. The biological functions of sVEGFR-1 still are not clear, but it seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor. |
| | EMRK2, HUMAN Preparation Products And Raw materials |
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