5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid

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5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid Basic information
Product Name:5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid
Synonyms:5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid;1-Piperazinepentanoic acid, 4-[(1,1-dimethylethoxy)carbonyl]-δ-oxo-;N-Boc-piperazine-C3-COOH;5-(4-Boc-1-piperazinyl)-5-oxopentanoic Acid
CAS:959053-53-3
MF:C14H24N2O5
MW:300.35
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Mol File:959053-53-3.mol
5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid Structure
5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid Chemical Properties
Safety Information
MSDS Information
5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid Usage And Synthesis
UsesN-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].
Biological ActivityN-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 [1].
IC 50Alkyl/ether
References[1]. Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid Preparation Products And Raw materials
Tag:5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid(959053-53-3) Related Product Information
4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Piperazinecarboxylic acid, 4-(4-amino-1-oxobutyl)-, 1,1-dimethylethyl ester 1-Piperazinecarboxylic acid, 4-(1,3-dioxobutyl)-, 1,1-diMethylethyl ester 5-(4-METHYL-PIPERAZIN-1-YL)-5-OXO-PENTANOIC ACID 4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazinenonanoic acid 1-Piperazinecarboxylic acid, 4-(1-oxobutyl)-, 1,1-dimethylethyl ester