Lipoxin B4 methyl ester manufacturers
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| | Lipoxin B4 methyl ester Basic information |
| Product Name: | Lipoxin B4 methyl ester | | Synonyms: | Lipoxin B4 methyl ester;6,8,10,12-Eicosatetraenoic acid, 5,14,15-trihydroxy-, methyl ester, (5S,6E,8Z,10E,12E,14R,15S)- | | CAS: | 97589-07-6 | | MF: | C21H34O5 | | MW: | 366.49 | | EINECS: | | | Product Categories: | | | Mol File: | 97589-07-6.mol |  |
| | Lipoxin B4 methyl ester Chemical Properties |
| Boiling point | 540.2±50.0 °C(Predicted) | | density | 1.056±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: unstable; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | | pka | 13.49±0.20(Predicted) |
| | Lipoxin B4 methyl ester Usage And Synthesis |
| Description | Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4 . LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; ) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM. | | Uses | Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM. | | References | [1] Serhan, et al. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. USA 81(17), 5335-5339 (1984). |
| | Lipoxin B4 methyl ester Preparation Products And Raw materials |
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