N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine manufacturers
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| | N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine Basic information |
| Product Name: | N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine | | Synonyms: | N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine;(1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(5-methyl-4-N-benzoylcytosine-1-yl)-2,5-dioxabicyclo[2.2.1]heptane;LNA-N4-Bz-methyl-C;N-benzoyl-5-methyl-2'-O,4'-C-methylene-Cytidine;N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine;Benzamide, N-[1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]-;N4-Benzoyl-LNA-5-methyl?cytidine;N4-Benzoyl-2'-O,4'-C-methylene-5-Me-cytidine | | CAS: | 206055-81-4 | | MF: | C18H19N3O6 | | MW: | 373.36 | | EINECS: | | | Product Categories: | | | Mol File: | 206055-81-4.mol |  |
| | N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine Chemical Properties |
| density | 1.58±0.1 g/cm3(Predicted) | | pka | 8.62±0.40(Predicted) |
| | N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine Usage And Synthesis |
| Uses | N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. | | References | [1] Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8. DOI:10.4161/cbt.3.11.1308 |
| | N4-Banzoyl-5-methyl-2'-O,4'-C-methylenecytidine Preparation Products And Raw materials |
| Raw materials | 2,4(1H,3H)-Pyrimidinedione, 1-[3-O-acetyl-4-C-[(acetyloxy)methyl]-2,5-anhydro-α-L-lyxofuranosyl]-5-methyl- (9CI)-->206055-62-1-->206055-49-4-->L-Lyxofuranose, 4-C-[(phenylmethoxy)methyl]-3-O-(phenylmethyl)-, triacetate (9CI)-->1-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione-->1,2-O-(1-methylethylidene)-4-C-[(phenylmethoxy)methyl]-3-O-(phenylmethyl)-L-Lyxofuranose-->((5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol-->1-((2R,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione-->3-O-Benzyl-4-(hydroxymethyl-1,2-O-isopropylidene)-alpha-D-erythropentofuranose-->Benzoyl chloride | | Preparation Products | 5-Methyl-2'-O,4'-C-methylenecytidine |
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