| Company Name: |
Shanghai Rechem science Co., Ltd.
|
| Tel: |
021-31433387 15618786686 |
| Email: |
sales@rechemscience.com |
| Products Intro: |
Product Name:LYN-1604 hydrochlorate
CAS:2216753-86-3
Purity:98% HPLC Package:50mg;100mg;1g;5g
|
| Company Name: |
Heze Development Zone chuangli Chemical Co., Ltd.
|
| Tel: |
0530-+86-530-529 6766，+86-15666160102 15666160102 |
| Email: |
info@chuangli-chem.com |
| Products Intro: |
Product Name:LYN-1604 hydrochlorate
CAS:2216753-86-3
Purity:98% Package:500mg/;1g/;5g/;10g/
|
LYN-1604 HCl manufacturers
|
| | LYN-1604 HCl Basic information |
| | LYN-1604 HCl Chemical Properties |
| form | Solid | | color | White to off-white |
| | LYN-1604 HCl Usage And Synthesis |
| Uses | LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1]. | | in vivo | LYN-1604 (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg; intragastric administration once a day for 14 days) inhibits the growth of xenograft TNBC by targeting ULK1-modulated cell death[1]. | Animal Model: | 24 female nude mice (BALB/c, 6-8 weeks, 20-22 g)[1] | | Dosage: | Low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg | | Administration: | Intragastric administration; once a day for 14 days | | Result: | Significantly inhibited the growth of xenograft MDA-MB-231 cells. The body weights of mice were stable. By the end of the experiment, the liver and spleen weight indexes of mice were slightly increased in parts of the groups, while the kidney weight index was not affected in all dose groups. |
| | IC 50 | ULK1: 18.94 nM (EC50) | | References | [1] Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701. DOI:10.1039/c6sc05368h |
| | LYN-1604 HCl Preparation Products And Raw materials |
|