THZ1 Dihydrochloride

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THZ1 Dihydrochloride Suppliers list
Company Name: Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.  
Tel: 025-66113011 13913916777
Email: cfzhang@aikonchem.com
Company Name: Shanghai Rechem science Co., Ltd.  
Tel: 021-31433387 15618786686
Email: sales@rechemscience.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com
Company Name: Amadis Chemical Company Limited  
Tel: 571-89925085
Email: sales@amadischem.com
Company Name: Shanghai Jizhi Biochemical Technology Co. Ltd.  
Tel: 021-4009004166/18616739031 18616739031
Email: 3007523370@qq.com

THZ1 Dihydrochloride manufacturers

  • (E/Z)-THZ1 2HCl
  • (E/Z)-THZ1 2HCl pictures
  • $92.00
  • 2026-07-27
  • CAS:2095433-94-4
  • Purity: 99.51%
  • Supply Ability: 10g
THZ1 Dihydrochloride Basic information
Product Name:THZ1 Dihydrochloride
Synonyms:THZ1 Dihydrochloride;(E)-THZ1 (dihydrochloride);N-(3-((5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide dihydrochloride;(E/Z)-THZ1 2HCl;THZ1 2HCl, 10 mM in DMSO
CAS:2095433-94-4
MF:C31H29Cl2N7O2
MW:602.52
EINECS:
Product Categories:
Mol File:2095433-94-4.mol
THZ1 Dihydrochloride Structure
THZ1 Dihydrochloride Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO: 100 mg/mL (156.50 mM);Ethanol: Insoluble
Water Solubility Water: Insoluble
Safety Information
MSDS Information
THZ1 Dihydrochloride Usage And Synthesis
Uses(E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect[1][2].
References[1] Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014;511(7511):616-620. DOI:10.1038/nature13393
[2] Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015;59(4):576-587. DOI:10.1016/j.molcel.2015.06.032
THZ1 Dihydrochloride Preparation Products And Raw materials
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