U 18666A
| 中文名称 | U 18666A |
|---|---|
| 中文同义词 | (3b)-3-[2-(二乙基氨基)乙氧基]-雄甾-5-烯-17-酮盐酸盐;化合物U18666A;U-18666A,胆固醇合成抑制剂;U-18666A,CHOLESTEROL TRANSPORT抑制剂;化合物U18666A,10 MM DMSO 溶液 |
| 英文名称 | U 18666A |
| 英文同义词 | U 18666A;3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL;3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL;3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE;(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE;(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE;U18666A,HCl;(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride |
| CAS号 | 3039-71-2 |
| 分子式 | C25H42ClNO2 |
| 分子量 | 424.06 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;抗体-二抗 |
| Mol文件 | 3039-71-2.mol |
| 结构式 |  |
U 18666A 性质
| 熔点 | 195-196.5 °C(lit.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O: 9 mg/mL at ≤60 °C |
| 形态 | 结晶 |
| 颜色 | 白色 |
| 水溶解性 | Soluble in water at 10mg/ml |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20°C 下保存长达 1 周。 |
| InChI | 1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H |
| InChIKey | ICPRVJHNLABCSA-UHFFFAOYSA-N |
| SMILES | [Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+] |
U18666A (U18) 是一种 intra-cellular cholesterol transport 的抑制剂，可抑制登革热病毒的侵入和复制。
Cholesterol.
U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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