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| | BencycloquidiumBromide Basic information |
| Product Name: | BencycloquidiumBromide | | Synonyms: | BencycloquidiumBromide;BCQB;3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)-1-methylquinuclidin-1-ium bromide;Bencycloquidium Bromide (Mixture of Diastereomers) | | CAS: | 860804-18-8 | | MF: | C21H32BrNO2 | | MW: | 410.4 | | EINECS: | | | Product Categories: | | | Mol File: | 860804-18-8.mol |  |
| | BencycloquidiumBromide Chemical Properties |
| | BencycloquidiumBromide Usage And Synthesis |
| Description | Bencycloquidium Bromide, also known as BCQB, is a muscarinic M3 antagonist potentially for the treatment of allergic rhinitis and chronic obstructive. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. BCQB showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M(3) pKi=8.21, M(2) pKi=7.21, and M(1) pKi=7.86); pA(2)=8.85, 8.71 and 8.57 in methacholine-induced contraction of trachea, ileum and urinary bladder, 8.19 in methacholine-induced bradycardia of right atrium in vitro, respectively. | | Uses | Bencycloquidium bromide, a muscarinic M(3) receptor antagonist, is an anticholinergic compound that acts as an anticholinergic bronchodilator. Bencycloquidium bromide can be used in the study for rhinitis[1][2]. | | References | [1] Qin Xu, et al. Determination of bencycloquidium bromide in rat plasma by liquid chromatography-electrospray ionization-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):209-14. DOI:10.1016/j.jchromb.2006.09.028
[2] Jun-Xia Jiang, et al. Characterization of bencycloquidium bromide, a novel muscarinic M(3) receptor antagonist in guinea pig airways. Eur J Pharmacol. 2011 Mar 25;655(1-3):74-82. DOI:10.1016/j.ejphar.2011.01.017 |
| | BencycloquidiumBromide Preparation Products And Raw materials |
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