|
|
| | Alx 40-4c Basic information |
| Product Name: | Alx 40-4c | | Synonyms: | D-Argininamide, N2-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl- (9CI);Alx 40-4c | | CAS: | 143413-49-4 | | MF: | C56H113N37O10 | | MW: | 1464.74 | | EINECS: | | | Product Categories: | | | Mol File: | 143413-49-4.mol |  |
| | Alx 40-4c Chemical Properties |
| density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | Alx 40-4c Usage And Synthesis |
| Uses | ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. | | IC 50 | SDF-1-CXCR4: 1 μM (Ki); APJ receptor: 2.9 μM (IC50) | | References | [1] Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86. DOI:10.1089/08892220151126508
[2] Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. DOI:10.1016/s0166-3542(03)00071-8
[3] Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. DOI:10.1016/s0042-6822(03)00185-5 |
| | Alx 40-4c Preparation Products And Raw materials |
|