dTRIM24 manufacturers
- dTRIM24
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2026-06-03
- CAS:2170695-14-2
- Min. Order: 1mg
- Purity: 98%min
- Supply Ability: 500mg
- dTRIM24
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- $77.00
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2026-04-20
- CAS:2170695-14-2
- Purity: 99.23%
- Supply Ability: 10g
- DTRIM24
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-
2025-03-16
- CAS:2170695-14-2
- Min. Order: 1MG
- Purity: 98
- Supply Ability: 100G
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| | dTRIM24 Basic information |
| Product Name: | dTRIM24 | | Synonyms: | dTRIM24;DTRM24;(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-{2-[2-(2-{2-[(3-{[1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-1,3-benzodiazol-5-yl]sulfamoyl}phenyl)formamido]ethoxy}ethoxy)ethoxy]acetamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide | | CAS: | 2170695-14-2 | | MF: | C55H68N8O13S2 | | MW: | 1113.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2170695-14-2.mol |  |
| | dTRIM24 Chemical Properties |
| density | 1.316±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:61.14(Max Conc. mg/mL);54.96(Max Conc. mM)
Ethanol:22.27(Max Conc. mg/mL);20.02(Max Conc. mM) | | form | Solid | | pka | 9.35±0.20(Predicted) | | color | White to off-white | | InChIKey | QUQTXFIMYFMULC-VOCJROMSNA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | dTRIM24 Usage And Synthesis |
| Uses | dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24. | | Definition | dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.
| | Biological Activity | dTRIM24, a conjugate of IACS-9571 a TRIM24 bromodomain ligand and VL-269 a VHL E3 ubiquitin ligase ligand, is a selective bifunctional degrader of bromodomain-containing transcriptional regulator TRIM24 (transcriptional intermediary factor 1a). dTRIM24 induces rapid and sustain proteasome degradation of TRIM24 in 293FT cells. | | storage | Store at -20°C | | References | [1] Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14(4):405-412. DOI:10.1038/s41589-018-0010-y |
| | dTRIM24 Preparation Products And Raw materials |
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