Roxatidine manufacturers
- Roxatidine
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- $0.00 / 1kg
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2026-05-13
- CAS:78273-80-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- Roxatidine
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- $1.00 / 1g
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2026-02-02
- CAS:78273-80-0
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 50tons
- Roxatidine
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- $0.00 / 1KG
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2025-06-27
- CAS:78273-80-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | Roxatidine Basic information |
| Product Name: | Roxatidine | | Synonyms: | ROXATIDINE;n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide;2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide;2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide;ROXATIDINE ENTERPRISE STANDARD;RoxatidineAcetateHclBase;ROXATIDINE(SUBJECTTOPATENTFREE);desacetyl-TZU-0460 | | CAS: | 78273-80-0 | | MF: | C17H26N2O3 | | MW: | 306.4 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 78273-80-0.mol |  |
| | Roxatidine Chemical Properties |
| Melting point | 59-60 °C | | Boiling point | 524.3±45.0 °C(Predicted) | | density | 1.137±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 25 mg/ml). | | pka | 13.34±0.10(Predicted) | | form | oil | | color | Colorless to pale yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 78273-80-0(CAS DataBase Reference) |
| | Roxatidine Usage And Synthesis |
| Description | Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4 | | Uses | Anti-ulcerative. | | in vivo | Roxatidine (20 mg/kg, p.o., a single dose for 1h before Compound 48/80 injection) ameliorates Compound 48/80 (HY-115768) (8mg/kg, i.p., a single dose for 1h)-induced allergic hypersensitivity and suppresses Compound 48/80-induced allergic inflammation in anaphylactic animal model[1].
| Animal Model: | Compound 48/80-induced anaphylactic shock mouse model[1] | | Dosage: | 20 mg/kg | | Administration: | p.o., a single dose for 1h before Compound 48/80 injection | | Result: | Increased the survival rate to 20% at 60 min after compound 48/80 injection. |
| | IC 50 | H2 Receptor | | References | [1] J G MILLS J R W. The pharmacology of histamine H2-receptor antagonists.[J]. Methods and findings in experimental and clinical pharmacology, 1989, 11 Suppl 1: 87-95.
[2] EU-JIN CHO. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages†[J]. Journal of cellular biochemistry, 2011, 112 12: 3648-3659. DOI:10.1002/jcb.23294
[3] HIROYUKI IMAEDA. Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia.[J]. Journal of Gastroenterology, 2011, 46 11: 1267-1272. DOI:10.1007/s00535-011-0447-1
[4] RENHAO ZE. Roxatidine Attenuates Degradation of Extracellular Matrix.[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017: 1156-1160. DOI:10.1016/j.biopha.2017.08.130 |
| | Roxatidine Preparation Products And Raw materials |
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