4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide

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Company Name: Shanghai Haohong Scientific Co., Ltd.  
Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Company Name: TargetMol Chemicals Inc.  
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Company Name: Hefei Molybdenum Kai Pharmaceutical Technology Co., Ltd  
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4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide Basic information
Product Name:4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide
Synonyms:4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide;Benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxy-2-pyridinyl)-;E17241
CAS:1060968-92-4
MF:C15H14N2O2S2
MW:318.41386
EINECS:829-239-6
Product Categories:
Mol File:1060968-92-4.mol
4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide Structure
4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide Chemical Properties
Boiling point 515.7±50.0 °C(Predicted)
density 1.431±0.06 g/cm3(Predicted)
solubility DMSO: Soluble: =10 mg/ml
form powder
pka7.60±0.10(Predicted)
color white to beige
Safety Information
MSDS Information
4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide Usage And Synthesis
UsesE17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet[1][2].
References[1] Sheng R, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024 Mar;172:116220. DOI:10.1016/j.biopha.2024.116220
[2] Xu Y, et al. E17241 as a novel ABCA1 (ATP-binding cassette transporter A1) upregulator ameliorates atherosclerosis in mice[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41(6): e284-e298. DOI:10.1161/ATVBAHA.120.314156
4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide Preparation Products And Raw materials
Tag:4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide(1060968-92-4) Related Product Information
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