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| Product Name: | KYL | | Synonyms: | KYL;L-Leucine, L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-;KYL peptide;KYLPYWPVLSSL;KYL TFA | | CAS: | 676657-00-4 | | MF: | C74H108N14O17 | | MW: | 1465.73 | | EINECS: | | | Product Categories: | | | Mol File: | 676657-00-4.mol |  |
| Boiling point | 1728.5±65.0 °C(Predicted) | | density | 1.290±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.29±0.10(Predicted) | | form | Solid | | color | White to off-white | | Water Solubility | Soluble to 2 mg/ml in water | | Sequence | H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH | | InChIKey | FZNPYIAZMDBRLC-RKNDTPCJSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| Uses | KYL peptide, an antagonistic peptide, selectively targets EphA4 receptor (IC50:4.22 μM, Kd:1.3 μM). KYL peptide binds to the ligand-binding domain of EphA4, effectively alleviates Aβ-induced synaptic dysfunction and synaptic plasticity defects in AD mice. KYL peptide can promote nerve regeneration after injury and modulating immune responses[1][2][3]. | | Biological Activity | KYL is a potent and selective EphA4 receptor tyrosine kinase antagonist th at inhibits EphA4-EphrinA5 interactions. KYL binds to the ephrin-binding domain of EphA4. | | IC 50 | EphA4: 4.22 μM μM (IC50); EphA4: 1.30 μM (Ki) | | storage | Store at -20°C | | References | [1] Wu B, et.al. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chem Biol. 2013 Jan 24;20(1):19-33. DOI:10.1016/j.chembiol.2012.10.015
[2] Lamberto I, et, al. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J. 2012 Jul 1;445(1):47-56. DOI:10.1042/BJ20120408
[3] Fu AKY, et, al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. DOI:10.1073/pnas.1405803111 |
| | KYL Preparation Products And Raw materials |
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