| Company Name: |
Twochem Co.Ltd. |
| Tel: |
021-58111628 15800915896 |
| Email: |
sales@twochem.com |
|
| | DMU2105 Basic information |
| Product Name: | DMU2105 | | Synonyms: | 2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)-, (2E)-;(2E)-3-(naphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one | | CAS: | 1821143-79-6 | | MF: | C18H13NO | | MW: | 259.3 | | EINECS: | | | Product Categories: | API | | Mol File: | 1821143-79-6.mol |  |
| | DMU2105 Chemical Properties |
| Boiling point | 463.7±37.0 °C(Predicted) | | density | 1.194±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 2.89±0.10(Predicted) | | color | Light yellow to yellow |
| | DMU2105 Usage And Synthesis |
| Uses | DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. | | IC 50 | CYP1B1: 10 nM (IC50); CYP1A1: 742 nM (IC50) | | References | [1] Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. DOI:10.1016/j.ejmech.2017.02.016 |
| | DMU2105 Preparation Products And Raw materials |
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