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| | 3BETA-HYDROXY-DELTA5-CHOLENIC ACID Basic information |
| | 3BETA-HYDROXY-DELTA5-CHOLENIC ACID Chemical Properties |
| Melting point | 232°C | | Boiling point | 522.8±23.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | refractive index | -39.5 ° (C=1, Dioxane) | | storage temp. | Refrigerator | | solubility | Dioxane (Slightly, Sonicated), DMF (Slightly), DMSO (Slightly, Heated, Sonicated) | | form | Solid | | pka | 4.76±0.10(Predicted) | | color | White to Pale Yellow | | InChI | 1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h5,15,17-21,25H,4,6-14H2,1-3H3,(H,26,27) | | InChIKey | HIAJCGFYHIANNA-ZSWKZNPUNA-N | | SMILES | C[C@]12CC[C@]3([H])[C@]4(CC[C@H](O)CC4=CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)O)C |&1:1,4,6,9,15,17,21,23,r| | | CAS DataBase Reference | 5255-17-4 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 3BETA-HYDROXY-DELTA5-CHOLENIC ACID Usage And Synthesis |
| Description | Cholenic acid is a monohydroxy bile acid. It is a cholesterol oxidation product formed by 7α-hydroxylation of 27-hydroxycholesterol (Item Nos. 14790 | 14791), as well as a precursor in the biosynthesis of chenodeoxycholic acid . Levels of cholenic acid are increased in patients with neonatal liver disease harboring mutations in CYP7A1, the gene encoding 7α-hydroxylase, as well as in patients with intrahepatic and extrahepatic cholestasis. | | Uses | 5-Cholenic Acid-3β-ol is a bile acid of which the metabolism in humans results in the primary bile acids lithocholic acid and chenodeoxycholic. It is found in hgher concentrations in meconium of premature human babies when compared to full term babies. | | Definition | ChEBI: 3b-Hydroxy-5-cholenoic acid is a steroid. | | IC 50 | Human Endogenous Metabolite | | References | [1] C LEE N B J K O Martin. Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway.[J]. Journal of Lipid Research, 1996, 37 6: 1356-1362.
[2] K D SETCHELL. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease.[J]. Journal of Clinical Investigation, 1998, 102 9: 1690-1703. DOI: 10.1172/jci2962
[3] K SUGIYAMA. Clinical evaluation of serum 3 beta-hydroxy-5-cholenoic acid in hepatobiliary diseases.[J]. Gastroenterologia Japonica, 1986, 21 6: 608-616. DOI: 10.1007/bf02774489 |
| | 3BETA-HYDROXY-DELTA5-CHOLENIC ACID Preparation Products And Raw materials |
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