Bractoppin manufacturers
- Bractoppin
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- $106.00
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2026-05-11
- CAS:2290527-07-8
- Purity: 99.65%
- Supply Ability: 10g
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| | Bractoppin Basic information |
| Product Name: | Bractoppin | | Synonyms: | Bractoppin;Methanone, [4-[(2-fluorophenyl)methyl]-1-piperazinyl](2-phenyl-1H-benzimidazol-6-yl)-;DNA break,Bractoppin,phosphopeptide,inhibit,DNA/RNA Synthesis,DNA damage,RAD51,G2 arrest,Inhibitor,BRCA1 tBRCT;(4-(2-Fluorobenzyl)piperazin-1-yl)(2-phenyl-1H-benzo[d]imidazol-6-yl)methanone;Bractoppin, 10 mM in DMSO | | CAS: | 2290527-07-8 | | MF: | C25H23FN4O | | MW: | 414.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2290527-07-8.mol |  |
| | Bractoppin Chemical Properties |
| Boiling point | 625.7±65.0 °C(Predicted) | | density | 1.299±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (603.18 mM; Need ultrasonic) | | pka | 10.70±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Bractoppin Usage And Synthesis |
| Uses | Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1]. | | References | [1] Jayaprakash Periasamy, et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12. DOI:10.1016/j.chembiol.2018.02.012 |
| | Bractoppin Preparation Products And Raw materials |
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