KY-02327
(KY02327) manufacturers
- KY-02327
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- $231.00 / 1mg
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2026-01-04
- CAS:2093407-25-9
- Min. Order:
- Purity: 93.86%
- Supply Ability: 10g
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| | KY-02327
(KY02327) Basic information |
| Product Name: | KY-02327
(KY02327) | | Synonyms: | KY-02327
(KY02327);KY-02327;1H-Indole-2-carboxylic acid, 5-hydroxy-1-[2-oxo-2-[[2-(1-piperidinyl)ethyl]amino]ethyl]-, ethyl ester;Ethyl 5-hydroxy-1-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)-1H-indole-2-carboxylate;Wnt,KY-02327,CXXC5,osteoblast,differentiation,inhibit,anti-osteoporosis,Dishevelled,KY 02327,bone,Inhibitor,anabolic,KY02327 | | CAS: | 2093407-25-9 | | MF: | C20H27N3O4 | | MW: | 373.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2093407-25-9.mol |  |
| | KY-02327
(KY02327) Chemical Properties |
| Boiling point | 627.2±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (267.77 mM; Need ultrasonic) | | form | Solid | | pka | 9.53±0.40(Predicted) | | color | White to off-white |
| | KY-02327
(KY02327) Usage And Synthesis |
| Uses | KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation[1]. | | in vivo | KY-02327 (20 mg/kg; p.o.; 5 sequential days per week for 4 weeks) successfully rescues bone loss in the ovariectomized (OVX) mouse model[1]. | Animal Model: | 8-week-old female BL6 mice (ovariectomized (OVX)-induced osteoporosis model mice)[1] | | Dosage: | 20 mg/kg | | Administration: | P.o.; administered for 5 sequential days per week for 4 weeks | | Result: | Newly formed bones which labeled with calcein were decreased in the femur of vehicle‐treated OVX mice.
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| | References | [1] Kim HY, et al. Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Mol Med. 2016;8(4):375-387. DOI:10.15252/emmm.201505714 |
| | KY-02327
(KY02327) Preparation Products And Raw materials |
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