| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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| | (S,R,S)-AHPC-PEG1-NH2 hydrochloride Basic information |
| | (S,R,S)-AHPC-PEG1-NH2 hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | form | powder or crystals |
| | (S,R,S)-AHPC-PEG1-NH2 hydrochloride Usage And Synthesis |
| Uses | Protein degrader builiding block (S,R,S)-AHPC-PEG1-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. | | reaction suitability | reactivity: carboxyl reactive
reagent type: ligand-linker conjugate |
| | (S,R,S)-AHPC-PEG1-NH2 hydrochloride Preparation Products And Raw materials |
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