| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:1883549-35-6
CAS:1883549-35-6
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
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| Company Name: |
R&D Systems, Inc
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| Tel: |
18003437475 |
| Email: |
rdname@qq.com |
| Products Intro: |
Product Name:Sephin 1
CAS:1883549-35-6
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| Company Name: |
Tocris Bioscience
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| Tel: |
+44 (0) 117 916 3333 |
| Email: |
customerservice@tocris.co.uk |
| Products Intro: |
Product Name:(2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt
CAS:1883549-35-6
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| | (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt Basic information |
| | (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt Chemical Properties |
| solubility | Soluble to 100 mM in DMSO |
| | (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt Usage And Synthesis |
| Uses | Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3]. | | Biological Activity | Sephin 1 is an inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available. | | storage | Store at -20°C | | References | [1] Chen Y, et al. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019;142(2):344-361. DOI:10.1093/brain/awy322
[2] Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348(6231):239-242. DOI:10.1126/science.aaa4484
[3] Thapa S, et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Mol Neurobiol. 2020;57(5):2206-2219. DOI:10.1007/s12035-020-01880-y |
| | (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt Preparation Products And Raw materials |
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